Intrinsic disorder: signaling via highly specific but short-lived association
نویسندگان
چکیده
منابع مشابه
Intrinsic disorder: signaling via highly specific but short-lived association.
Association between signaling proteins and their cellular targets is generally thought to be highly specific (implicating a high association constant, K(a)) and, at the same time, transient or short-lived (corresponding to a high dissociation rate constant, k(d)). However, a combination of high K(a) and high k(d) would lead to a high association rate constant (k(a) = K(a)k(d)), which poses a pr...
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ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2012
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2011.11.002